Tovi, with a few exceptions ( pickpocket) you can activate your skill as first or second hand skill - meaning left/right click. But if I read his post correctly => he has no skill icons next to his portrait <img src="/ubbthreads/images/graemlins/confused.gif" alt="" />
Kiya
http://www.kiya1.de/beyond/actgeneral/democom10.PNG@Jowi => please look at my screenie and concentrate on the right upper part: do you have icons on clicking on the hands? If so - just click on the icon you want to use - and depending on the hadn you chose, you see "prim" or "sec" on the icon. And then you do what Tovi described => right click for the sec skill (in my case firing elemental missile) or left click, if you chose this skill as prim.