Is your screen blank from the moment you double click the icon to start the game?
Or do you get the copy protection check first then the screens goes blank?
No loading screens of any kind first?
the first thing that happens after the cd check is the intro movie that would run at 640x480 res. If it's crashing while trying to run this movie then that could be the problem.
Go into the directory of the game, not sure of the exact location but you'll find the movie intro and acts movies in there. Can you run them without a crash?
I'm not a techhy but I generally fix my problems by the process of elimination. IE. if a, b and c don't work, then answer must be d.
...oh and when you said you have 2 monitors do you mean both hooked up to you PC?
If so rather than just disabling the connect how about severing it completely just to see if there's a problem there.
Any help?