Several times, after playing for a while, I've seen a weird thing happen.
When I press a key to do somthing - say, an F8 to select a spell - the whole menu interface at the bottom turns into a few horizontal colorful lines.
I haven't found any way to fix it other than exiting the game and reloading.
If you save the game in that state and load it after restarting the game, for a split second it loads with the weird lines, but then the menu replaces them.