Simple combat: Modified attack roll vs. Modified defense roll. If it succedes, apply damage. Spells modify one of these categories. Do not bother with saving throws against spell x or ability y. Combat can be made creative with creative weapons (ie. scenery and traps).
So we want a Universe that isn't medieval? How about: Wild West, Modern, Futuristic, Space-faring, Animal, Post-Apocalyptic, Cyber Punk, Horror, Private Investigation/Film Noir, Superhero, your favourite tv/comic/book series, Alternate Earth...
Also, what will be available in this Universe? Technology, Magic, Law, Disease, Money, Aliens/Races, ...
One idea I can think of for a less violent setting would be Cyber Punk. There's more espionage and hacking involved. The available classes (if any) wouldn't give rise to a particually combat effective individual. Sure they could use a gun, but it's more for protection and intimidation than assault.
What other settings are people interested in?
