Picklock. It does not work. Need I say more?
Yes: pickpocket doesn't work, either. The idea that your character can add a point or two of skill in this and remove 5-10 large items from anybody's possession is remarkable, to say the least.
You didn't mention the interface. Frankly, I think that was one of the major drawbacks to the game. It's a mess, as is the transfer of materials between your characters. Of course, others may differ in their opinions on this.