I recall someone mentioned having a similar problem with quick saves (default hotkey IIRC) on a laptop but it worked on a desktop (or vise versa).
Can you still quick load the most recent quick save? If you do a standard save and delete all the quick saves, do they start working again? If you alt tab out of the game (or exit) and in Windows Explorer browse to the '..\Beyond Divinity\savegames' folder, do you have any quick save folders with a .tmp extension?
I can still quickload my most recent QS, yeah if i delete all QS's than I can start QSing again. It seems to have a limit of no more then 4 QS's. And none have .tmp extension