Try a different optical drive, if available.
Are you shutting down all non-essential programs (especially anti-virus) before trying to start the game, and did you do so before installing?
There is a manual install procedure for Divine Divinity;
Troubleshooting Tips (& manual install procedure)If nothing else helps with Beyond Divinity, in the error message, click the 'Information' button, then when that finishes, click the 'View Report' button. Save the resulting text file somewhere, optionally zip it, and email it to Larian (support@larian.com) with a description of the problem. They can create a file the copy protection can use to check your system on startup, rather then the play CD.
