Was SafeDisc3 protecting that game?
B/c that piece of piracy protection is known to not let you play the game if you have the following installed:
CDClone (especially this one)
Alcohol 120% (especially this one)
Nero
Roxio
Daemon Tools
Some of the game protected by SD3 that I have heard given that error for "CD/DVD Emulation Software found", form what I know:
Sims 2
Painkiller
Doom 3
