@brokenunity
Its not about having or not having viruses on the cd... its to do with the antivirus's interference with regestry entries... scanning files while the game is trying to take control of them... or in some cases even locking certain files so that the game cannot access them.
My personal antivirus has never caused any hassles with any of my games (Trend Micro's Pc Cillin), but i know for a fact that Norton is prone to cause lock-ups in the game, causes problems with the copy protection, and also to report that it has been corrupted by the game (which it doesnt get corrupted - after a reboot everything is back to normal). There has been numerous reports of other antivirus packages causing similar problems....
BD doesnt need any internet connection, or LAN connection while you are playing.... so there should be no risk of infection while your antivirus is off while playing the game.