Ubereil,
I have played Ultima 7 and Serpent's Isles on DOS box.
Sometimes, restarting Windows XP (assuming that's what you have) in MS-DOS mode works too.
To do that, insert a blank diskette in your drive. Right click on the drive in "My Computer" and choose "create MS-DOS bootdisk". Then restart your computer. You need to make sure booting from a diskette is set before booting from the HD in your BIOS.
Nero: I played Warcraft 2 on Win 98. Have you tried the compactibility mode under XP?
