What I find as one of the more frustrating things is Dogs becoming hostile for no reason. I've been checking on them to make sure they're not hostile and when they are finding out why. Aside from the obvious like attacking them.
One problem is Lar, the dog that appears in the Dwarven Bread Inn. He only appears after the player has been to the Dwarf village, Glenborus. Otherwise there's a Dwarf in that room that offers gems. If you enter the room while Lar is there he turns hostile. If you leave the room he becomes friendly again. You can tell by watching his icon on the minimap. If you attack he remains hostile. A problem I've run into is passing by the back of the inn. While walking around the building I triggered the Dwarf and had a conversation with him through the wall. I think a few times I also triggered Lar's aggression the same way. But since I wasn't actually in the room I couldn't leave it to turn him back.
Another big one is that other creatures are apparently aligned with the Dogs. In the hill area next to Glenborus there's a large, green wasp that won't attack. It appears green on the minimap. I think one time I set off the Dogs by killing this wasp thinking it was just an ordinary one. In Verdistis there's a swarm of Mosquitoes. When the Dogs are friendly so are they. And attacking one makes both species hostile.
Theory: All of these animals are actually Imps in disguise.
Side note: I may be imagining this but in the room at the start of the game the dark and light areas on the back wall look like they're in the shape of a dog.
