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You are not missing much experience by not being able to complete the murder quest, though Mardaneus would have taught you a level of Restoration (again, not a huge loss).

Josephine is generally considered to be the most difficult opponent in the game, but there are various techniques to defeat her.
Chasing Josie...


I am at level 30, and it seems a bunch of these posters, have some of their magics maxed out. I don't have any of my magics maxed out at the moment.

I think I made a screwed up build. I will find a way though.