i'm finished the game in epic-mode and had no problems.
@elliot
you get many additional bags to enlarge your inventory (180 free slots).
you don't need a town portal scroll, simply activate the first teleporter in the town and you can open town portals at any time you wish by pressing the "L"-key, then select your active teleporter and enjoy your travel. you can select and travel to any active teleporter you've found.
