So if you load the save and hit the esc key right away, the save menu option is disabled?
Try deleting all of the files in the '..\Divine Divinity\Run\Dynamic' folder.
This folder is used as a cache for the game. Files are created / copied there from the save game folder when you load, and written / copied from that folder when you save a game. The files will be re-created as required the next time you start Divinity. If there was a corrupt file in that folder, deleting the files should fix the problem.
If you hit the space bar during the load process, so the game starts off paused, does that make a difference? Maybe interrupting the character movement (click somewhere else to change direction, etc) will help (can't hurt to try, anyway).
