When run, the patch checks the registry for the install path and language version, and gives the error you stated when it does not find the expected information. Do you have the North American or UK English version of the game?
In Windows XP, if you installed the game from an account without administrative privileges, that might prevent the registry entries from being created. A recent system restore or an over aggressive registry cleaner could also be the problem, in which case re-installing the game from an account with administrative privileges should help. If Windows boots straight to the desktop, you just have one account, and it has administrative privileges.
Also, you can email Larian (support@larian.com) to get a vbs file that can create the required registry entries. A description and a reg file that works for the UK / North American version is near the end of
this topic.
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