From the main menu, under Options, there is a list of hotkeys you can change. AFAIK you can not change mouse button settings within the game.

Tutorial-Changing F1-F12 hotkeys to different keys


From the manual (pdf version);

Keyboard Shortcuts
SPACEPause/Unpause the game
CTRLTarget closest enemy to mouse cursor.
CTRLWhen dragging multiple objects from your inventory in the world and releasing the mouse cursor while holding CTRL pressed, split up the objects.
SHIFTWhen holding shift and moving the mouse cursor to the side of the screen, you can scroll away from your player character. Release shift to jump back to your player character.
ALTShow object boxes describing interesting objects in the environment
RToggles auto-run mode on/off. When toggled on, a left mouse click causes your character to run towards the designated point instead of walking to it.
CToggles combat mode on/off. draw your weapon (if you have none, show your fists) or put down your weapons
MToggle mini map Open the inventory (back pack)
EOpen the equipment plate
TOpen the player statistics plate
CTRL+LQuick load
CTRL+SQuick save
LOpen the "Load Game" screen
SOpen the "Save Game" screen
ESCBack to main menu
QOpen the quest log (diary)
AOpen the auto map (diary)
CTRL+F12 Assign hotkeys (F1-F12)
CTRL+F11Create a screenshot in the "Captures" sub directory


There is a configuration file edit to skip the intro videos (see here), which you may want to do after you have seen them at least once.
With the latest game version, this will also eliminate the need for the Play CD, except for a couple cases (the blessing ceremony, after hitting the gong late in the game, and at the end of the game). These are the same limitations as with the no-CD hack.
The version number is shown in the bottom right corner of the main menu (latest is 1.0034A, otherwise you may need the patch). The DVD version has already been updated, CD versions may or may not be, depending on when they were produced.

You can change the game resolution to other than supported resolution by editing the config.div file (in Notepad or another text editor). Note: the game itself may be fine at higher than supported resolutions, but opening the auto-map can cause the game to crash.