I think it is a little early for such a discussion, at least as far as the details. Today's impervious copy protection may not be all that great by the time the game is ready to be released.
In general terms, any kind of serial number verification would require an internet connection, which would be seen as a disadvantage by many consumers that either don't have a reliable internet connection or who pay per-minute charges. Any interruption between your ISP and Larian's server could leave you locked out of the game (so no playing on plane, etc). A grace period would pretty much have to be added to the verification system, but that adds a potential security vulnerability.
CD verification (at least) is probably likely, though hopefully the system used will not refuse to accept SCSI drives. Starforce didn't have a problem with my SCSI DVD drive, until I replaced my SCSI CD burner with an IDE DVD burner, after which it would only accept the BD play CD in an IDE drive (CD/DVD drive emulators often show up as SCSI devices). I have 2 IDE optical drives, which are slower, louder and take longer to spin up than the SCSI drive.
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