Well, you've got to be really careful when dealing with such an issue.
For example:
a) Some people tend to use no-cd hacks(or "cracks" as some like to say) 'cos they'd like to keep their cd/dvd drive free. So, there might be complaints if they can't do that.
b) Certain formats of copy-protection do have a certain failure rate. Thus, it might actually alienate the customers IF the protection fails to recognise that the dvd is legit. It used to happen a lot but not sure about now. Therefore, it's preferable that Larian test the copy protection thoroughly before release. Otherwise, customers might flock to using cracks and other "methods" so they can enjoy their legit game or actually return the product.
c) If Larian wants to use a serial key number, then make sure that the publisher ships it. I heard this happened with the Canadian customers who purchased Witcher: was quite a slip there.
