Some of you seem to think that if you have your hand on WASD you can't push any other buttons on the keyboard. The # keys are right above WASD, so you put your combat skills in the number buttons on the left for fast switching, and less reflexive skills like lockpicking to the right. FPS games have been doing this for as long as I can remember, its not hard to switch skills/weapons using WASD, trust me, I play them all the time. This is all assuming that the hotkeys will be the number keys not the function keys, which would be only slightly less swift. Not to mention that it sounds like the mouse wheel is freed up to flip through skills rapidly as well.
