I think people tend to forget that it's not because you have a combat system that consists of keyboard combinations, that it's "twitch-based". There are games who bring really good, intuitive and realistic combat which is easy to control; such as Severance: Blade of Darkness (granted, it's not a good game, but it does have a good combat system)and Gothic II (better stance as you improve your weapon skill, which also means different combos, and you have to time and direct your swings)
Personally I think point-and-click games are out of date. It's sort of sad that most RPG's (and most action games, for that matter) still haven't come up with a combat system that immerses the player. It's not because you have to time it right and aim it right, that combat depends on player skill. Not at all, character skill will still be the decisive factor, but making you control the character personally will add much to the involvement and will make for a much more interesting game.
Not that the tried-and-true method doesn't work; the Infinity-type isometric view, also used for DD, is a classic and very good view and system. But all games have been 3D for quite a while now; it's time to evolve. I'm sure Larian agrees, and has put quite a bit of thought in the combat system.
