This is likely going to be a publisher call, with details like that coming along very late (i.e. just before release, so as not to scare people away).
Offline games should never have online activation and none should have activation limits, ever. Definitely two big pet-peeves of mine. However, only BioShock caused me any issues, and that was due to the DRM detecting that I had run Process Explorer at some point without a reboot before installing. Annoying, but I got over it enough to play the game and enjoy it. Unfortunately, the experience stayed with me and now I'm leaning negative on a lot of different DRM. Give me back a good ole media check any day.
