Combat works pretty good for me as far as the camera operation and control. Got right hand on mouse and wasd on the left. I remapped 3 hotkey spells to be easier to cast: 1 spell on Q, 1 on F and the skill i use to bust barrels on the RMB.
Targeting is a bit of a problem if i want to be very selective with who i shoot because the game auto targets. Also it seems as though the enemy has longer range, so if i am in melee and whip out my bow to drop an enemy with magic or bow who is already engaged on me, i first have to run to them.
That is a situation where rush comes in handy, which is a skill where you close in fast on the enemy and knock it down. Only sometimes it seems rush misses the target and flies right by or if it hits my character gets stunned while the enemy is knocked down, but still is nice to close in for melee.
