A tip for Vista users I haven't read here before and that solved all of my stuttering problems:
Install the game to your home directoy/drive (so, usually C:\*) and not to any secondary partition or alternate physical drive. Vista combined with some games/copy protection seems to hate that...
Installed on drive D in my case: stuttering video sequences, stuttering speech and audio, a MINUTE of delay before opening the options menu or initiating some dialogues.
Installed on "C:\Program Files (x86)\Divinity II - Ego Draconis" and it runs smoothly in 1680x1050, max settings...
Do you use a raidsetup or one single harddrive? Because anyone with two or more drives should NOT install the game on the same hd as windows is on. If you're experiencing stuttering, it's propably an individual issue with your system and has nothing to do with installing it on another drive.