There are a few DVD drives which are seemingly incompatible with SecuRom, we found out in the Drakensang forum. Which means that yours can be one of them, perhaps.

We had a list of user-added compatible drives there, which I posted here somewhere ...

Other possibilities could include faulty RAM modules.

When you find a big kettle of crazy, it's best not to stir it.
--Dilbert cartoon

"Interplay.some zombiefied unlife thing going on there" - skavenhorde at RPGWatch