If there's a problem with your DVD, you won't get a crash.
I'd also assume firewall/anti-virus don't play a role.

Does other stuff that makes heavy use of system-ressources run?

I'd more assume it's something strange in your windows. Check you have the newest versions of all drivers (usually graphics- and sound-drivers matter). Uninstall all codec-packs you might have installed. Re-install Direct X.

What graphics card do you have?

If all that above does not help, I fear you'll have to re-install your windows (with the newest drivers then), pay attention what else (3rd-party-stuff) you install. If it STILL crashes then and you have some mainstream-graphics-card (nvidia or ATI; you are not playing on a laptop, no?) you really might have some hardware-issue. But really check your drivers/codecs first! (Download newest versions, uninstall existing stuff, re-install the new stuff, leave out codecs or so for now).