Is it possible to get all achievements (Xbox 360) even though you play the game at the easiest difficulty?

P.S.: I know I can find descriptions of the achievements on different sites around the internet, but I don't want to read the secret achievements' descriptions and thereby spoiling the story line.

"Look at you, hacker. A pathetic creature of meat and bone. Panting and sweating as you run through my corridors. How can you challenge a perfect immortal machine?"