I have the exact same problem as ArzTheFenix: in the Imp Castle and the Warriors' Guild I cannot pick up items, rifle the dead, or descend the staircases, although these items are highlighted when the cursor is on them.

Other information:
Operating system: Windows XP, SP3, all current security updates installed, administrator rights
Size of RAM: 1 GB
Graphics card and driver version: ASUS A9800XT/TVD/N/256M/A (Radeon 9800 XT),
driver version 6.14.10.6844
additionl hardware: ...
additional software running in the background: ZoneAlarm, McAfee, LCDC (panel display)
Size of swap file: 1.5 GB, fixed by administrator
Game version and patch: version 1.004 of Divine Divinity, downloaded from GOG,
compatibility modes OFF
size of partition/hard drive, free space left: 277GB total, 157GB free
DirectX version: 9.0c
colour depth 16 bit or 32 bit: 32 bit
additionals: have you used a fix download before: No

Hope you can patch this.

Thanks for a great game.

Garth