I have only once encountered this bug once and that was when i was about to fight a boss (no names for spoilers sake). After i won the first fight and he ran off, the game wouldn't respond, it's like it froze but the avatars where still moving idly and my creature doing his usual business. I had to start from a save point prior to that for it to move past that point. I was so worried that i was going to loose many hours that i had put in :C (like 20+ hours.)
Touch wood, this hasn't happened to me again.