Mindreading gives you some nice items at times. To avoid the save/reload before mindreading: just look at the cost. Let's say you are in Broken Valley and the average mindread is 66 EXP, then you mindread someone and it costs like 125 EXP, then that's when you should try it.
Also, you can get skill points and stats points by mindreading.
Save/reload is the same as 'cheating' in my book.

Use mindreading wisely and it will payoff for you.