There is not much different between the PC and Xbox versions (other than the usual platform differences). The text is reportedly larger and easier to read on the Xbox version, and the camera angle fixed (on the PC the angle is determined by the camera distance).
PC or Xbox 360?From what I've read, character build, skill choices and amount of exploration can make a significant impact on difficulty. Generally if an area is too hard a different approach may help, or there are other areas that can be done first.
You can try the PC demo; if you have no issues getting it running normally, then you shouldn't have a problem with the full version. There are a couple serious outstanding issues some people have run into, with a few workarounds that have helped in some cases.
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