Have the same exact problem as the OP/MrBeez
Have tried disabling the Physx, didn't help...will try deleting that graphics line (graphicoptions.xml)that StarKillar suggested.
I also re-installed my AMD Dual Core Optimizer.
I've played with different resolutions and graphic settings.
So far I can not get past the "New Game" loading icon...it just CTD and I get the Microsoft Error Report Box to send the report. Oddly there is NO Error Code listed though..?
My info/DxDiag is here btw for comparison.
http://www.larian.com/forums/ubbthreads.php?ubb=showflat&Number=402812#Post402812Good luck to all affected, maybe at some point well be able to figure this out

Regards
ps @ MrBeez - I believe the new 1.03 patch is for the English (NA) version as well.