Oh, dear, I can't access the old forum, although I've got some links - there was a post in the tech. Forum about mouse probs. The only advice I can give you is: Make a backup from your saves, uninstall, shut down the PC, defragment and then reinstall the game again, shutting off all background programs like Antivir, Outlook, Firewall, internet etc.
I gather all your drivers are up-to-date? I have a Logitech mouse and only use the MS standard drivers for a wheel mouse, same goes for my keyboard.
The game will be hard without the right click: active skills work with it. And even if you're a warrior: No swirl attack possible then... And for some quests you have to use the right mouse.
Did you have the prob from the very beginning? Or did it start with a corrupt savegame?