Do the saves still work in the CD version?
In the original download version of DD games started in the CD/DVD version could usually be loaded ok, but then saving was disabled (a couple people mentioned crashing IIRC). I think that was fixed with the update, though.
Did you backup the saves directly to CR-R/DVD-R and restore them by copying the folders back? If the files in the save folder are marked as read-only the game will crash near the end of the loading process.
Check the number of files in the saved game folder (in '..\Divine Divinity\Run\savegames'). Missing files might cause the game to crash when trying to load. A new game should have 22 files, after going to either Verdistis or the Dark Forest it should have 27, after going to both it should have 32, etc.