I have not had any problems with the jumping so far in D2:ED (had to try the disappearing platforms in the depleted ore mine a couple times to get the timing right), but then I'm playing the Xbox version. Playing Psychonauts on the PC I was ok at the start with keyboard and mouse, but had to switch to a gamepad once the acrobatics started getting more involved. There were a few very frustrating points for jumping, but I made it to the final level (then had to quit when I couldn't find a cheat for the timer or the health of the NPC you needed to protect). I watch a video of the last section on Youtube, and that confirmed my conclusion that it wasn't worth trying to learn the right pattern of twitches fast enough to get through it. The rest of the game was very good, though.