Someone with Win 7 64 and an ATI HD4870 reported occasional graphical artifacts (with the UK or Australian version of the game), which they fixed by running the game as administrator and disabling desktop composition. Maybe that would help? Right click on the D2:ED shortcut, select Properties and switch to the Compatibility tab.

Have you tried running at different resolutions?


First Aid Kit for Divinity II

First Aid : when Div2 does not start or crashes