Well...thats not a whole lot of information.
Are you saying you used the card for your second time through of Div1?
The system reqt's for D2 are significantly higher than the original installment.
Give a little more information and be more specific on what you mean. But the best answer (if you already own it) is of course to install it and see if it works. Trial and error tends to be the best way to do things...