i allso have the same problem:

http://www.larian.com/forums/ubbthreads.php?ubb=showflat&Number=411280#Post411280

it happens when you quicksave them quickreload inside the first town. what happens is that you respawn outside of the town near the gate insted inside where you saved and all the doors in all the biukdibgs we go black and wont work.

please fix it sad