I maxed Mana Efficiency (5), Lockpick (5) and Dual Wielding (13), and boosted Bleed up to level 10 (max is 14, but the effect per skill point barely improves after level 10). With all other skills I got by with just a couple levels (in many cases level 1 was good enough).
I forgot to mention the main reason I unlearned my skills the first time. There is a skill to increase your inventory capacity, which is not needed once you have the battle tower, and can use the chest there to store spare equipment, books, plants, minerals and pretty much anything else you wish. Getting back the 4 skill points I put into that skill was the largest single adjustment I made when unlearning my skills. Playing again I'd know better what I needed to keep and what I could get rid of, and wouldn't need that skill.
I was also hoping to be able to re-distribute the starting slayer skills (I didn't need level 1 of weapon expertise I wasn't going to use), but they stay at level 1; only points you add get removed. You do recover the point from the bonus skill from you choice in Farglow (Poison Arrow for a ranger, Whirlwind for a warrior...), though.