I'm not familiar with D2D, so don't know what Comrade would be doing differently than launching the game directly. Have you tried contacting them, as well?
Have you tried right clicking on the divinity2.exe file, or a shortcut to it, and running it as administrator? In the compatibility options you could also try disabling desktop composition.
Maybe some of the suggestions in the topic
Never ending loading screen. 100% of the time. could help, though it is not the same issue.
There have been several topics with suggestions for performance problems.
Choppy game - possible fixFor people with stuttering graphicsGraphics .. Performance .. TipsFirst Aid Kit for Divinity IIFirst Aid : when Div2 does not start or crashes