yes ive had the game crash during an autosave a couple times.

i detailed the post in the main discussion forums for DKS.

this game does seem prone to crashing.
during the 15 or so hours ive played its crashed -

once during a cutscene in maxos tower
twice autosaving
once whilst battling at broken valley quarry
once whilst running around broken valley

250gb 360 slim. game installed to hard drive. uk pal version bought from gamestation.