I've only really hated the lack of Quest Markers in FoV, because the place is so cramped and it's hard to mark where NPCs are, and there are a lot of them. For example, when going for the Raccoon Rune, I forgot where 75% of those NPCs were by the time I got their item. I didn't do any part of that quest until much later after I had already mind-read about every single one of them, and refinding them was a hassle.

Overall, the majority of item-based quests, where you have to return an item to someone in the town, I really wish they had markers. I didn't have a problem in ED, but that's because you could mark yourself where they were, but if I marked where every NPC was, I'd have 10,000 markers on my map by the time I was done.

You shouldn't have Quest Markers for places you have no idea where they are, but when you know exactly where an NPC is that you have a quest item for, it should tell you where you can find them.