I'm doing OK with 2-handed weapons, but in FoV I saw something which was definitely a bit annoying.
I purchased the Blade of the Beheader, 2-handed sword from the market square.
Blade of the Beheader
Melee Damage: 13-239
Magic Damage: 63-77
(Total Damage: 76-356)
+64 Hitpoints
+6 Conditioned Body
+7 Strength
1 Charm Slot
2 Enchantment Slots
Later on I found the goblin trader and saw the Blood Blade.
Blood Blade
Melee Damage: 24-213
Magic Damage: 53-65
(Total Damage: 77-278)
+10 to Strength
+10 to Melee Damage
+66 to Hitpoints
+6 to Critical Chance
+3 to Bleed (Passive Skill)
2 Charm Slots
2 Enchantment Slots
I accidentally purchased the Blood Blade before I realized it was a one-handed weapon. But look at those absurd stats! That's a one-handed weapon! It's nearly as powerful in damage as a two-handed weapon, and you can have TWO weapons there. It also has better bonuses. You can equip TWO of them. That's nuts.