Hmm..
I looked up the error code 14001 - It seems to be a problem with the Visual C++ redistrubutable install. This is required for any programs that were written in Visual C++ - if the redistributable is missing/corrput/wrong version, the program can't run, hence the error code.
Now I've got the Steam version on Windows 7, but hopefully your install should be similar. Find the "Divinity 2" program folder under "Program Files", and hopefully you'll have a subfolder called "support".
Under this should be a folder "VCRedist", in which you'll find the installers for two version (v80sp1 and v90sp1). Clicking on them should give you the option to "repair" or "uninstall". Repair might work, but if it doesn't, a complete uninstall and reinstall of both redistributables might work.
I'm guessing here, but it makes sense - reinstalling the game wouldn't necessarially reinstall the redistributable, as the redistributable is a shared resource amongst all programs on your system.
You could also try reinstalling the PhysX drivers and the DirectX drivers also found in the games "Support" folder, but apart from that I'm all out of ideas - maybe someone from Larian tech support can help.
