Well, at least you can take solace in the fact that you do not have to activate all the runes to advance to the Maxos Temple(Maybe you don't even need to activate the runes at all, but I haven't tried this out as of yet). Same with the "to find a wizard" quest line, I apparently missed out on one of the clues during my first play through, decided that I'm not herping through that steaming pile of derp, just guessed where the final orb should go and jumped into the Antideluvian pit once I got lucky. Whereas in other games you'd most likely be doomed to consult a guide to move on if the same thing happens.