Axel is worried about you, Joram! It took him a good few days to get over Lana's death, the poor thing.
Anyway, Charm and Blind can indeed be real life-savers and ideal for the kind of character you're playing. But for 'lone' bosses like Amdusias, be sure to bring your creature! A warrior-style one will force him into melee combat and with a little bit of luck you'll have found an Undead head for it with Fatality.
Also, in areas where there are poison/fire/lava floors (e.g. the Bandit Camp or Barnabus' cave), be
very careful, as on nightmare difficulty those mean instant death!