Thanks a lot for the responses. I will definitely use them all, and this will I think be kind of fun. Improvisation is missing in many games as your hand is held the whole time. Kind of reminds me of my time in MMOs.
I was able to find one chest that I missed, but after 30 reloads the best two-hander I could find was level 14, and my character is 21.
I will definitely try brewing some strong potions. I've been pretty unlucky with creature parts - on the necro merchant I've never found a mage head worthwhile.