In my very first playthrough I simply missed the Mine in Broken Valley where you can find the Crystal Skull ... It's even more funny since I was all the time (that first playthrough) confused when I hear two NPC's talking about the Mine in the Black Boar Inn and I was always thinking they talk about the Mine quarter (the place where you can find Williams) ...
I was totally confused ... :haha:

2) I also missed the Forlorn Cave, a nice one with a funny quest for the two sisters ...

Missed a few skillbooks first time (Farglow, Black Boar Inn etc etc ... )

And to know I play all rpg's "thoroughly" ... but I love it to search and the game secrets are well hidden !! smile

On 7th of february 2015 : I start a new adventure in the Divinity world of Original Sin,
it's a Fantastic Freaking Fabulous Funny ... it's my All Time Favorite One !