There's a worthwhile post on Swen's blog addressing DRM:

http://www.lar.net/2012/01/02/how-i-couldve-been-prevented-from-being-a-pirate/

I'm not a big fan of DRM if only for the little inconveniences. Unless we're talking about 'always online DRM' I can stomach it for a game I want to support. My only hope is that the game sells exceptionally well, in order to get Larian excited and confident enough to stick to the turnbased, party RPG style.