Baldur's Gate had bounty hunters and NPC's actively hunting you down as you traveled and in towns you could also encounter them. Certain party members would also turn against you and refuse to be with you if you had a low reputation.
I'm guessing Original Sin will be like Divine Divinity where we get NPC's who refuse to talk to us and guards attacking us on sight. So long as guards don't give the player 100,000 exp upon death then there's no worrying about the player "poerleveling" via killing everyone. I found that the only benefit to murdering people in BG and DD was that you could get some good loot and items without paying but it's been problematic when there's no merchants to trade with and I need some potions.
So all in all I have no problem with how DD handled evil characters but I'm hoping Original Sin will also spawn in some NPC's who come to hunt us down like BG had.
+1 This sounds like a great idea. Not only will it increase the depth of the game, but it will definitely increase replay-ability. I would love to see the interactions between dark-aligned and light-aligned characters with the NPC's.