I've never used it in 2 playthroughs. I think it makes it more realistic and challenging if you have to learn from your mistakes.Some skills are better than others but you need to learn that through experience. Many walkthroughs give you tips about character creation but I prefer to create my own character, flaws and all, rather than rely entirely on what someone else thinks is a good build, although I have gotten a few good tips here, like the value of a few Priest skills.